Workpackage 4 – Clinical Neurophysiology


Clinical Neurophysiology methods, especially EEG, provide valuable information for diagnosing the epilepsies, with specific patterns identified in many diseases requiring expert interpretation. Thus, integration of recent advances into EpiCARE is essential. However experience and expertise is required to recognise the advantage of accurate recording and interpretation; geographical variation requires specifically to be addressed here.

SCORE is a computer-based system for EEG assessment and reporting, which reduces the inter-observer agreement in EEG interpretation and is based on a consensus proposal by a group of European experts endorsed by the International League Against Epilepsy – Commission on European Affairs (ILAE-CEA) and the European Chapter of the International Federation of Clinical Neurophysiology (EC-IFCN). During the development process, SCORE was tested and adjusted by applying it to real, clinical data.

Electrical source imaging is part of the presurgical evaluation of patients with drug-resistant focal epilepsy. The software packages that will be used in this study have CE mark for this specific medical use. In spite of being part of the clinical standard, the evidence for the accuracy and clinical utility of these methods are derived from several smaller-scale and retrospective studies. The PROMAESIS study will provide solid evidence of the accuracy and clinical utility of automated ESI.


  • Development of a web-based platform for secure exchange and storage of neurophysiological data, integrated with the databases of other work-packages
  • Integration of SCORE into EpiCARE
  • Validation of automated EEG source imaging in presurgical evaluation of patients with drug resistant focal epilepsy


  • Implementing the SCORE system for improving the quality in clinical EEG
  • Implementing automated EEG source imaging into presurgical evaluation, as a useful tool in the multimodal approach



Pr. Sándor Beniczky, MD

Danish Epilepsy Center
Denmark/SCORE consortium


Pr. Sándor Beniczky, MD