Workpackage 5 – Neuropsychology


Behavioural and cognitive comorbidities in epilepsy are very common. They are often present already at epilepsy onset and before. Cognitive and behavioural assessments can reveal differential diagnostic indicators of epilepsy subtypes and syndromes, particularly when related to data from imaging, electrophysiology, pathology, and genetics (see other work packages). Furthermore it allows monitoring of disease dynamics (progress and control), and it can be used for the outcome and quality control of applied treatments (surgical, stimulatory, medical, behavioural comprehensive care). With the E-Neuropsych task force within the funded pilot ERN E-pilepsy an initiative was taken which aimed at the homogenization and distribution of best evidence based neuropsychological practice. The result was the availability of a core standard test battery of evidence based neuropsychological and behavioural instruments. The battery covers developmental and adult neuropsychology and addresses various cognitive and behavioural domains. The tool box was implemented in a web based E-Neuropsych platform for data entry, evaluation, collection and communication across EU reference centres for epilepsy surgery. E-Neuropsych represents one node within a diagnostic network which also comprises imaging (structural/functional), and electrophysiological (invasive/non-invasive) diagnostics and evaluation tools. E-Neuropsych, can be extended and adapted to all other questions concerning the epilepsies. Within a large network of clinics it can well be expected that for rare pathologies enough data can be collected so that their cognitive and behavioural aspects along with disease development and treatment can be defined.


  • Set up of a common evidence based diagnostic toolbox for assessing and monitoring behavioural comorbidities of the epilepsies
  • Set up of a registry for cognitive and behavioural comorbidities in epilepsy across European epilepsy centres
  • Discerning differential diagnostic and prognostic criteria for different disease conditions in epilepsy from the beginning of the disease and along its natural course
  • Outcome and quality control of different treatment options
  • Development of new therapeutic or prophylactic approaches to behavioural comorbidities in epilepsy



Pr. Christoph Helmstaedter, PhD

University Hospital Bonn

Bonn, Germany

Pr. Christoph Helmstaedter, PhD