Clinical Trials Outcomes for Seizure Severity Assessment

This Special Interest Group (SIG) was created to address a major gap in clinical trial design for epilepsy: the lack of standardized and meaningful measures of seizure severity. While most trials rely on seizure frequency as the primary outcome, this does not adequately capture the real-life impact of epilepsy on patients’ quality of life.

Current Activities

• Initial mapping of existing seizure severity scales
• Identification of key domains (clinical signs, patient-reported symptoms, psychosocial impact)
• Creation of subgroups to work on population-specific tools
• Inclusion of patient advocacy representatives (ePAGs) in the development process