EpiCARE Research Council – Current Grant Opportunities

Deadline:06.03.2025 17:00.

Budget: 1 million euros (2 years project)/ 1,5 million euros (3 years project)

Link

Alliances for Innovation aim to strengthen Europe’s innovation capacity by boosting innovation through cooperation and flow of knowledge among higher education, vocational education and training (both initial and continuous), and the broader socio-economic environment, including research.

They also aim to boost the provision of new skills and address skills mismatches by designing and creating new curricula for higher education (HE) and vocational education and training (VET), supporting the development of a sense of initiative and entrepreneurial mind-sets in the EU.

Alliances for Education and Enterprises are transnational, structured and result-driven projects, in which partners share common goals and work together to foster innovation, new skills, a sense of initiative and entrepreneurial mind-sets.

They aim to foster innovation in higher education, vocational education and training, enterprises and the broader socio-economic environment. This includes confronting societal and economic challenges such as climate change, changing demographics, digitisation, the emergence of new, disruptive (deep tech) technologies such as artificial intelligence and rapid employment changes through social innovation and community resilience, as well as labour market innovation.

Alliances for Education and Enterprises bring together enterprises and both higher education and vocational training providers to work together in partnership. Operating within one economic sector or several different economic sectors, they create reliable and sustainable relations and demonstrate their innovative and transnational character in all aspects. While each partnership must include at least one VET and one higher education organisation, they can address either both or one of these educational fields. The cooperation between VET and higher education organisations should be relevant and should benefit both sectors.

They intend to achieve one or more of the following aims:

• fostering new, innovative and multidisciplinary approaches to teaching and learning: fostering innovation in education design and delivery, teaching methods, assessment techniques, learning environments and/or developing new skills
• supporting skills development in the deep tech domains; supporting Europe’s innovation capacity by broadening its talent pool in these new, disruptive technologies
• fostering the setting up of incubators within education and training institutions across Europe
• fostering corporate social responsibility (e.g. equity, inclusion, climate change, environmental protection and sustainable development)
• stimulating a sense of initiative and entrepreneurial attitudes, mind-sets and skills in learners, educational staff and other workers, in line with the Entrepreneurship Competence Framework (EntreComp)
• improving the quality and relevance of skills developed and certified through education and training systems (including new skills and tackling skills mismatches)
• facilitating the exchange and co-creation of knowledge between higher education and vocational education and training, research, the public sector and the business sector
• building and supporting effective and efficient higher education and vocational education and training systems, which are connected and inclusive, and contribute to innovation

Higher education institutions are encouraged to use the HEInnovate self-assessment tool before applying, above all if they are coordinating the proposal. HEInnovate will help them identify their strengths and weaknesses in terms of entrepreneurship and innovation. The proposal and the consortium composition can therefore be better prepared and combine all the necessary expertise.

Eligible participating organisations (Who can apply?)

The applicants (beneficiaries and affiliated entities, if applicable) must be:

• public or private organisations established in an EU Member state of third country associated to the Programme such as
  • Higher education institutions
  • VET providers
  • networks of VET providers
  • small and medium-sized or large enterprises (including social enterprises)
  • research institutes
  • non-governmental organisations
  • public bodies at local, regional or national level
  • organisations active in education, training and youth
  • intermediaries that represent education, training or youth organisations or enterprises
  • accreditation, certification, recognition or qualification bodies
  • Chambers of commerce, industry or labour, chambers of skilled crafts
  • European or national social partners
  • hospitals or other care institutions, including long-term care
  • authorities responsible for education, training or employment at regional or national level
  • employment services
  • national statistics offices
  • economic development agencies
  • sectoral or professional associations
  • sector skills councils
  • bodies providing career guidance, professional counselling, information services and employment services

Budget: The available budget for this call is 35 Mio. € (approx.).

Link

Aims of the Call

The overall objectives of the JTC2025 will be to

• Support research projects in human health on pharmacogenomic strategies for personalised medicine approaches that address one or more of the following aspects:
  • identification of new pharmacogenomic markers or signatures using (multi)-omics data in relation to drug or drug combination.
  • validation of a pharmacogenomic marker or signatures using (multi)-omics data in predicting drug or drug combination outcomes.
  • use pharmaco-omics strategies to determine the right dosage, the efficacy of treatments and/or the risk of adverse drug response and non-response to treatment to tailor personalised treatment pathways, including combined treatments (multi-medication).
• Encourage and enable interdisciplinary collaborations, i.e. multi-actor research by engaging a range of other relevant disciplines such as pre-clinical and clinical research, bioinformatics/health informatics/data research, ELSA research, implementation research or health economics research connected to the proposed research topic, including end-user perspective analysis to support the implementation of the research outcomes into clinical practice.
• Encourage cross-sectorial collaborations, by including the private sector (e.g. SMEs, small and medium-sized enterprises), industry, as well as regulatory/HTA agencies and patient organisations.
• Establish participatory research, i.e. active representation of patients or citizens as part of research projects.

Research projects in all disease areas will be welcome.

General (Eligibility) Conditions for Application

Whilst applications will be submitted jointly by groups from several countries, the individual applicants of each group will be funded by the respective regional/national EP PerMed funding organisation of the individual applicants. The applications are therefore subject to eligibility criteria and regulations of individual funding organisations.

Joint research proposals may be submitted by applicants belonging to the following categories (subject to regional/national funding regulations):

1. Academia (research teams working in universities, other higher education institutions) or research institutes;
2. Clinical/public health sector (research teams working in hospitals/public health and/or other healthcare settings and health organisations). Participation of clinicians (e.g. medical doctors, nurses) in the research teams is encouraged;
3. Private for-profit (industry) partners, e.g. SME (small and medium-sized enterprises) and private non-profit partners, e.g. foundations, associations or non-governmental organisations.

Budget: Projects may be funded at the $25,000, $50,000, or $75,000 level. The project duration is one or two years.

No deadline

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The Lennox-Gastaut Syndrome Foundation (LGS Foundation) is a non-profit organisation based in the United States. Its mission is to improve the lives of individuals affected by Lennox-Gastaut Syndrome, a rare form of childhood-onset epilepsy, through research, programmes and education. Projects may be on any novel topic in LGS but must be directly relevant to LGS, which is characterized by specific seizure types and hallmark EEG features.

The LGS Foundation Cure LGS 365 Research Grants provide funding to seed new basic, translational, and clinical Lennox-Gastaut Syndrome research projects.

Applications must be submitted by email. Letters of Intent (LOIs) may be submitted at any time; there are no deadlines. Selected applicants are invited to submit a full proposal.

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Deadlines: Project applications can be submitted until

• 1 February  for the summer meeting of the foundation committees in June
• 1 September for the winter meeting of the foundation committees in February

of each year.

In accordance with one of the desires of the donors, special attention is devoted by the foundation institutions to medical research. At present the foundation is focusing its support on the field of “Molecular causes in the development of illnesses”.  This programme supports molecular biological studies of illnesses whose development is based on genetic defects or with which gene variants contribute to the development of complex illnesses.

In the area of “Molecular causes in the development of illnesses”, molecular biological studies of illnesses are supported whose development is primarily based on genetic defects or whose gene variants contribute to the development of complex illnesses.

Studies may be performed on cell culture and/or animal models, but should at least in part be performed on human tissue specimens and/or cells bearing relevance to illnesses. This only applies for applications submitted for support of projects.

• Project proposals are only accepted from researchers that have a Ph.D. and relevant experience in the priority field of research. They should generally have two to four years’ experience in post-doctoral research and want to set up or expand a small working group of their own with the support of the Foundation. The position of the applicant should be funded by the host research Institute.
• It is generally not possible to obtain funding for one’s own position.
• Firmly established researchers and scientists (holders of chairs, directors of clinics) are not eligible for support of projects.

The following projects are assigned preference:

• The functional analysis of genes, gene products and their signal transduction pathways for monogenic and complex genetic illnesses in vitro and in vivo, whereby the work plan should also contain studies on human tissue specimens and/or cells
• The characterisation of cell and animal models that have already been established for the study of genetic illnesses (with molecular biology methods)
• The analysis of predisposing genes or therapies which modify illnesses (‘personalised medicine’) if this holds out the promise of additional findings being generated on the mechanistic causes of disease formation

Support is not provided for:

• Purely methodological studies
• Descriptive genetic studies of populations as well as linkage and association studies
• Purely drug screening projects
• Research projects without any direct connection to an illness
• Research projects involving the development of an animal model that is to be studied in the grant period applied for
• Research projects that do not involve any studies on human tissue specimens and/or cells bearing relevance to illnesses
• Research projects relating to infectious diseases
  Diagnostic and primarily therapy-oriented projects

TYPES OF COSTS

PERSONNEL COSTS

Complete personnel costs can be applied for in the case of research staff with doctoral degrees under

TVL-E13. In the case of research staff who do not have doctoral degrees, their pay is generally based on

65% of a TVL-E13-position. In countries other than Germany, the personnel costs are to be stated

according to the salary costs arrangements applicable there, i.e. total wage costs including the employer’s

share as a total sum.

In the case of applying for personnel costs for clinician scientists, the foundation assumes that the

planned staff will be put on leave at least 80 per cent of their working time at the clinic. Confirmation of

this from the clinic is to be submitted with the application.

Non-academic personnel are paid at the appropriate TVL level.

Student helpers or research assistants should be paid according to the rates prevailing at the institution

involved; the foundation is to be notified hereof through the budget plan accompanying the application.

TRAVEL COSTS

Funds to defray travel costs that are directly connected with the project can be applied for. In addition to

reasonable travel and overnight accommodation costs, up to € 28 a day can be granted to defray the costs

of meals when traveling within Germany (rail travel 2nd class or air travel economy class).

In the case of travel abroad, the daily or monthly rates for the respective country of travel can be applied

for to defray overnight accommodation and meal costs.

WHAT CANNOT BE APPLIED FOR

› Staff resources for the own post

› Financial resources for construction work

› Financial resources to procure office furnishings and equipment that are usually part of the basic

furnishings at universities and institutes

› Generally, no financial resources are granted to defray overhead costs

The Global Innovation Fund (GIF) is currently inviting applications for its Grants program to support breakthrough solutions from for-profit firms, non-profit organisations, researchers, and government agencies to maximise their impact and catalyse meaningful change.

Deadline – Ongoing

The Global Innovation Fund invests in the development, rigorous testing, and scaling up of new products, services, business process, or policy reforms. Through its grants, GIF supports these breakthrough solutions from for-profit firms, non-profit organisations, researchers, and government agencies to maximise their impact and catalyse meaningful change.

If you are a non-profit and your innovation does not involve generating revenues from users or customers, a grant is likely to be most appropriate.

Stages of Funding

GIF has a staged funding approach, whereby the amount of funding available is tiered according to the level of maturity of your innovation and the activities proposed. The three tiers are:

Pilot – the innovation is at an early stage but you have a credible plan for how it can be developed and tested in a real-world setting. Funding of up to USD 230,000 is available to test core assumptions around operational, social, and financial viability.

Test and transition – the innovation has already shown promise of success at a small scale, and you have some information on your operational, social, and financial viability which you want to solidify before you scale. Funding of up to USD 2.3 million is available to support further growth and generate additional evidence on whether the innovation can achieve social impact and market viability, for commercial innovations.

Scale – the innovation has a strong evidence base and logistically credible plan for scaling to reach millions of people. Funding of up to USD 15 million is available to expand the reach of innovations with a view to reaching millions of people in the long term if successful.

What they Fund?

At GIF, they believe that innovation, by which they mean any solution that has potential to address an important development problem more effectively than existing approaches, can come from anyone, anywhere.

This means that they accept applications working in any sector in any developing country.

Any type of organisation may apply. This includes social enterprises, for-profit companies, non-profit organisations, government agencies, international organisations, and research institutions in any country. It is recommended that individual innovators, entrepreneurs, or researchers apply through an affiliated organisation.

Eligibility Criteria

Any type of organisation may apply. This includes social enterprises, for-profit companies, non-profit organisations, government agencies, international organisations, and research institutions in any country. It is recommended that individual innovators, entrepreneurs or researchers apply through an affiliated organisation.

Ineligible

GIF is open to innovations which meet their criteria in any sector or country. However, there are some activities they do not fund. These include:

• Theoretical research, or purely lab-based activities that are not linked to implementation of a specific proposed real-world pilot or demonstration project.
• Approaches that are only applicable in a single country (unless the innovation is expected to scale to a large proportion of one of the world’s most populous developing countries).

More information

The FamilieSCN2A Hodgkin-Huxley Grant program was created to honor the achievements of Dr. Alan Hodgkin and Dr. Andrew Huxley and their innovative modeling of action potentials, as well as their contributions which laid the groundwork for neuroscience research on the molecular, cellular, and circuit levels.

Unsolicited, year-round LOIs accepted. Full application invitations on a rolling basis as long as funds are available.

Link

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These research grant awards are intended for established, experienced, independent investigators affiliated with a research or academic institution whose proposed projects seek to investigate hypotheses directly related to hypothalamic hamartoma syndrome. Proposals are scored based on the quality of preliminary data, research design, feasibility, investigator’s qualifications, and overall impact.

Investigators applying for a research grant should ensure their proposed project addresses the needs of the hypothalamic hamartoma syndrome community and Hope for HH’s mission to support research toward better understanding, improved treatments and ultimately a cure for hypothalamic hamartoma syndrome.

Eligibility:

Applicants should be affiliated with a research or academic institution (excluding for-profit companies), may be US or foreign based, established in their field, and in good standing with their institution.

Our research priority areas include:

• Research that helps identify patient trends, characteristics, epidemiology, or other clinical aspects of hypothalamic hamartoma syndrome and/or its comorbidities.
• Research that will encourage the development of novel therapies to eliminate or prevent seizure progression or halt the progression of other comorbidities associated with hypothalamic hamartoma syndrome.
• Research that helps to understand, predict, and prevent SUDEP

Link: will be updated

Deadline:Full proposal submission deadline: 29 April 2025 at 17:00 Brussels time.

Indicative budget

Applicant consortia will be competing for the maximum financial contribution from IHI JU of up to EUR 20 000 000. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board.

IHI JU estimates that an IHI JU financial contribution of EUR 5 000 000 to 10 000 000 would allow a proposal to address these outcomes appropriately. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board. Nonetheless, this does not preclude the

submission and selection of a proposal requesting different amounts

Scope:

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies etc. that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Accordingly, applicants must assemble a collaborative public-private partnership consortium reflecting the integrative and cross-sectoral nature of IHI JU, and capable of addressing the challenge(s) and scope of the IHI JU Specific Objective 1 “contribute towards a better understanding of the determinants of health and priority disease areas”

Applicants are encouraged to use the opportunity offered by emerging industrial technologies (e.g. innovative imaging methods, robotics or artificial intelligence) to provide better targets and approaches to develop new and more precise personalised health innovations for prevention, diagnosis and therapy, as well as facilitating good health while aging.

Applicants should consider the following points in their proposals:

1. a) address an unmet public health need based on at least one of the below:

• the high burden of the disease for patients and/or society due to its severity and/or the number of people affected by it;
• the high economic impact of the disease for patients and society;
• the transformational nature of the potential results on innovation processes where projects are not focused on individual disease areas (e.g. health data analytics).

1. b) demonstrate the ability to translate research into innovative solutions that can be integrated/implemented into the healthcare ecosystem and/or in industrial processes.

Expected impacts to be achieved by this topic

The actions to be funded under this topic are expected to achieve the following:

1. a) contribute to one or more of IHI JU’s expected impacts linked to Specific Objective 1 as set out in the IHI JU SRIA, i.e.:

• patients benefit from preventive treatment or early disease intervention before onset of symptoms;
• prevention and early diagnosis of disease combined with better understanding of the mechanisms involved, leading to the development of more cost-effective strategies;
• patients benefitting from improved healthcare through regular monitoring of critical parameters using validated tools; development of new vaccine strategies targeted to specific sub-populations;
• increased preparedness of EU healthcare systems for disease outbreaks

1. b) contribute to strengthening the competitiveness of the EU’s health industry, via increased economic activity in the development of health technologies, in particular, integrated health solutions, thus fostering European technological leadership and the digital transformation of our societies.

Link : will be updated

Deadline: Full proposal submission deadline: 29 April 2025 at 17:00 Brussels time.

Indicative budget

Applicant consortia will be competing for the maximum financial contribution from IHI JU of up to EUR 80 000 000. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board.

IHI JU estimates that an IHI JU financial contribution of EUR 8 000 000 to 15 000 000 would allow a proposal to address these outcomes appropriately. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board. Nonetheless, this does not preclude the submission and selection of a proposal requesting different amounts.

Scope:

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies etc. that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Accordingly, applicants must assemble a collaborative public-private partnership consortium

Proposals could aim, for example, to break down fragmentation between various disciplines of medicine including computational and technological areas to accelerate innovations from early discovery to patient treatment.

Among others, proposals may aim to integrate diverse components (e.g. from focused mission-based research projects, collaborative platforms, databases, AI/ML to diagnostics, medicinal products, medical devices, wearables, digital solutions) in order to foster the development of people-centred, ambitious, large-scale and transformative solutions along the healthcare pathway from beginning to end, including treatment discovery.

Activities may include novel and harmonised approaches to data generation and federation, algorithm optimisation and applicable ML outputs, as well as activities to deliver open-source computational outputs such as machine learning methods for prediction at scale derived from a collaborative, community driven ecosystem.

Other examples are activities that catalyse data-driven AI/ML-influenced discoveries and therapies (e.g. integration of in vitro, in vivo approaches), (small molecules) screening platforms, manufacturing processes such as mass protein expression, diagnostics and prognostics for early and adapted treatment, including multimodal disease and/or cross-therapy area applications or management approaches. Proposals may address specific target populations, and/or support challenging unmet needs and treatment gaps.

Applicants should consider the following points in their proposals:

1. a) address an unmet public health need based on at least one of the below:

• the high burden of the disease for patients and/or society due to its severity and/or the number of people affected by it;
• the high economic impact of the disease for patients and society;
• the transformational nature of the potential results on innovation processes where projects are not focused on individual disease areas (e.g. health data analytics).

1. b) demonstrate the ability to translate research into innovative solutions that can be integrated/implemented into the healthcare ecosystem and/or in industrial processes.

Expected impacts to be achieved by this topic

The actions to be funded under this topic are expected to achieve the following:

1. a) contribute to one or more of IHI JU’s expected impacts linked to the IHI JU’s Specific Objective 2, as set out in the IHI JU SRIA, i.e.

• breaking down fragmentation between various disciplines of medicine and technological areas in order to conceive and develop technologically and socially innovative, people- centred, integrated healthcare solutions that can seamlessly be introduced in healthcare systems;
• fostering development of safe and effective innovative health technologies and their combinations thanks to new and harmonised approaches to data generation;
• better and faster integration of future products, services and tools along the healthcare pathway (including health promotion and disease prevention), responding to patients’ specific needs and leading to improved health outcomes and patient well-being;
• patients and industry benefit from innovative manufacturing processes such as 3D printing, on-demand small-scale good manufacturing practice (GMP) synthesis, on-site portable production systems etc.;
• green transition enabled across all aspects of healthcare, both in the delivery of healthcare to patients, and in the technologies and products that emerge from a competitive European industry.

1. b) contribute to strengthening the competitiveness of the EU’s health industry, via increased economic activity in the development of health technologies, in particular, integrated health solutions, thus fostering European technological leadership and the digital transformation of our societies.

Link: will be updated

Deadline: Full proposal submission deadline: 29 April 2025 at 17:00 Brussels time.

Indicative budget

Applicant consortia will be competing for the maximum financial contribution from IHI JU of up to EUR 30 000 000. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board.

IHI JU estimates that an IHI JU financial contribution of EUR 8 000 000 to 15 000 000 would allow a proposal to address these outcomes appropriately. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board. Nonetheless, this does not preclude the submission and selection of a proposal requesting different amounts

Scope:

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies etc. that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Accordingly, applicants must assemble a collaborative public-private partnership consortium.

For example, proposals may aim to foster the development of integrated healthcare solutions, combining different technological areas and taking into account the needs of patients and citizens to, among others: a) facilitate patient contributions to R&I activities; b) support shared decision-making with healthcare professionals; and c) enable self-management of disease and health, de facto engaging in social innovation. This may imply, amongst others, the development of harmonised patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs), as well as the development of methods to elicit people’s preferences and digital tools to enable patient involvement.

Applicants should consider the following points in their proposals:

1. a) address an unmet public health need based on at least one of the below:

• the high burden of the disease for patients and/or society due to its severity and/or the number of people affected by it;
• the high economic impact of the disease for patients and society;
• the transformational nature of the potential results on innovation processes where projects are not focussed on individual disease areas (e.g. health data analytics).

1. b) have people-centric, rather than product- and pathology-centric, approaches – the focus being the patient and citizen journey through health care, with the help of most suitable health technologies and social innovations and taking account of demographic trends;
2. c) demonstrate the ability to translate research into innovative solutions that can be integrated/implemented into the healthcare ecosystem and/or into industrial processes.

Expected impacts to be achieved by this topic

The actions to be funded under this topic are expected to achieve the following:

1. a) contribute to one or more of the IHI JU’s expected impacts linked to the IHI JU’s Specific

Objective 3, as set out in the IHI JU SRIA, i.e.

• raised awareness among citizens and patients on their own role in managing their health;
• improved patient adherence to prevention programmes and medical interventions;
• people, including vulnerable populations (e.g. elderly and children as well as their carers and/or representatives), are better able to make informed decisions with their healthcare professionals about prevention, treatment interventions and disease management;
• increased frequency and quality of cooperation between patients, citizens and industrial stakeholders in the development of healthcare solutions, in particular integrated care solutions;
• patients benefit from prevention and treatment better adapted to their needs through improved diagnostic and monitoring;
• integrated healthcare solutions, including those based on the use of digital solutions, better responding to the needs and preferences of patients and citizens, supporting an inclusive approach;
• successful implementation of digital solutions supporting people-centred care;
• facilitated introduction of innovative solutions for improved home care of patients;
• healthcare solutions assessed according to criteria that matter to patients and citizens (in particular, PROMs and PREMs) contributing to achieving people-centred healthcare.

1. b) contribute to strengthening the competitiveness of the EU’s health industry via increased economic activity in the development of health technologies, in particular, integrated health solutions, thus fostering European technological leadership and the digital transformation of our societies.

Link : will be updated

Deadline: Full proposal submission deadline: 29 April 2025 at 17:00 Brussels time.

Indicative budget

Applicant consortia will be competing for the maximum financial contribution from IHI JU of up to EUR 30 000 000. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board.

IHI JU estimates that an IHI JU financial contribution of EUR 8 000 000 to 15 000 000 would allow a proposal to address these outcomes appropriately. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board. Nonetheless, this does not preclude the submission and selection of a proposal requesting different amounts.

Scope:

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies etc. that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Accordingly, applicants must assemble a collaborative public-private partnership consortium.

For example, proposals may aim at supporting the generation, pooling, integration and sharing of high- quality, harmonised, interoperable data (either existing or generated de novo), as well as the use of advanced analytical tools (including Artificial Intelligence, computational modelling and simulation or digital twin approaches). They may also support the development of better assistance systems for healthcare professionals to facilitate timely decision-making during disease course, thereby improving  patient outcomes.

Applicants should consider the following points in their proposals:

1. a) address an unmet public health need based on at least one of the below the high burden of the disease for patients and/or society due to its severity and/or the number of people affected by it;

• the high economic impact of the disease for patients and society;
• the transformational nature of the potential results on innovation processes where projects are not focussed on individual disease areas (e.g. health data analytics).

1. b) demonstrate the ability to translate research into innovative solutions that can be integrated/implemented into the healthcare ecosystem and/or into industrial processes.

Expected impacts to be achieved by this topic

The actions to be funded under this topic are expected to achieve the following:

1. a) contribute to one or more of the IHI JU’s expected impacts linked to the IHI JU’s Specific Objective 4, as reflected in the IHI JU SRIA, i.e.:

• wider availability of interoperable, quality data, respecting FAIR (findable, accessible, interoperable, reusable) principles, facilitating research and the development of integrated products and services;
• improved insight into the real-life behaviour and challenges of patients with complex, chronic diseases and co-morbidities thanks to m-health and e-health technologies;
• advanced analytics/artificial intelligence supporting health R&I, resulting in a) clinical decision support for increased accuracy of diagnosis and efficacy of treatment; b) shorter times to market; c) wider availability of personalised health interventions to end-users; d) better evidence of the added value from new digital health and artificial intelligence tools, including reduced risk of bias due to improved methodologies.

b) contribute to strengthening the competitiveness of the EU’s health industry via increased economic activity in the development of health technologies, in particular, integrated health solutions, thus fostering European technological leadership and the digital transformation of our societies.

Link : will be updated

Deadline: Full proposal submission deadline: 29 April 2025 at 17:00 Brussels time.

Indicative budget

Applicant consortia will be competing for the maximum financial contribution from IHI JU of up to EUR 20 000 000. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board.

IHI JU estimates that an IHI JU financial contribution of EUR 5 000 000 to 10 000 000 would allow a proposal to address these outcomes appropriately. NB: this amount is indicative and subject to change, pending approval by the IHI Governing Board. Nonetheless, this does not preclude the submission and selection of a proposal requesting different amounts.

Scope:

With a view to harnessing new science and technologies, this topic aims to fund pre-competitive research and innovation for novel tools, methods, technologies etc. that will foster the development of health innovations to prevent, intercept, diagnose, treat, and manage diseases and enable recovery more efficiently.

Accordingly, applicants must assemble a collaborative public-private partnership consortium.

For example, proposals may aim to develop methods and tools to assess the added value of emerging and converging health technologies, taking into consideration different stakeholders’ value dimensions, to support harmonised approaches for evidence generation.

Applicants should consider the following points in their proposals:

1. a) address an unmet public health need based on at least one of the below:

• the high burden of the disease for patients and/or society due to its severity and/or the number of people affected by it;
• the high economic impact of the disease for patients and society;
• the transformational nature of the potential results on innovation processes where projects are not focussed on individual disease areas (e.g. health data analytics).

1. b) demonstrate the ability to translate research into innovative solutions that can be integrated/implemented into the healthcare ecosystem and/or into industrial processes.

Expected impacts to be achieved by this topic

The actions to be funded under this topic are expected to achieve the following:

1. a) contribute to one or more of the expected impacts linked to the IHI JU’s specific objective 5 as reflected in the IHI JU SRIA, i.e.:

• seamless and successful implementation in healthcare settings of cross-sectoral innovations, integrated products and services delivering proven benefits to patients, healthcare systems and society as a whole;
• patients have improved access to innovations that meet their needs and those of the healthcare systems;
• better informed decision-making at different levels of the healthcare system (authorities, organisations), that will in turn contribute to a better allocation of resources towards cost- effective innovations;
• faster entry to the market of cost-effective innovative solutions developed by industry, which could translate to a positive effect on their R&I investments

1. b) contribute to strengthening the competitiveness of the EU’s health industry, via increase economic activity in the development of health technologies, in particular, integrated health solutions, and thus fostering European technological leadership and the digital transformation of our societies.

Link

The aim of the call is to enable scientists in different countries to build an effective collaboration on a common interdisciplinary research project based on complementarities and sharing of expertise, with the expected impact being future use of the results to benefit patients. Projects will focus on a group of rare diseases or a single rare disease following the European definition

Topic List:

Research studies on therapies using small molecules, small non-coding chemically synthesized nucleic acid-based therapies, repurposed drugs or biologicals (e.g., antibodies or proteins such as enzymes, immune modulators or growth factors etc.). Proposals must cover at least one of the following areas:

1. development of novel therapies in a preclinical setting through cell, organoid and animal model studies, molecule screening or use of in silico or artificial intelligence models
2. development of predictive and pharmacodynamics biomarkers correlated to the efficiency of the therapy in a preclinical setting that could serve as surrogate endpoints
3. replication of pre-clinical studies in an independent lab to increase validity of exploratory findings
4. pre-clinical proof of concept studies for evidence of pharmacological activity in vitro and in vivo, pharmaco-kinetics and pharmaco-dynamics of the drug and first toxicology and safety data
5. studies to support readiness for initiating clinical trial authorization conforming to regulatory requirements Translatability into humans should be the key focus of the project, and applicants should demonstrate access to relevant scientific or regulatory expertise (e.g., through innovation task forces or competent national authorities).

Excluded Approaches and Topics

The following approaches and topics are excluded from the scope of the JTC 2025:

• ATMP therapies (gene therapy medicinal product (including mRNA-based therapies), somatic cell therapy medicinal product, tissue engineered product, according to EMA definition).
• Development of new cell/organoid/animal models, which should already be established.
• Set-up or extension of natural history studies / patient registries.
• Interventional clinical trials to prove efficacy of drugs/treatments/surgical procedures/medical procedures. This includes studies comparing efficacy, e.g., two surgical techniques or therapies, and projects whose main objective is the implementation of a clinical phase IV pharmacovigilance study.
• Projects focusing only on rare neurodegenerative diseases that are within the focus of the Joint Programming Initiative on Neurodegenerative Disease Research (JPND). These are: Alzheimer’s disease and other dementias; Parkinson’s disease (PD) and PD-related disorders; Prion diseases; Motor Neuron Diseases; Huntington’s disease; Spinal Muscular Atrophy and dominant forms of Spinocerebellar Ataxia. Interested researchers should refer to the relevant JPND calls. However, childhood dementias/neurodegenerative diseases are eligible.
• Rare infectious diseases, rare cancers and rare adverse drug events in treatments of common diseases. Rare diseases with a predisposition to cancer are eligible.

The maximum duration of the project is three years.

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Budget: Application budgets are not limited but need to reflect the actual needs of the proposed project.

Deadline: February 05, 2025

Eligibility: Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.

Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Purpose of this funding opportunity announcement is to encourage collaborations- between life science and physical science- that: 1) apply a multidisciplinary bioengineering approach to solve biomedical problems; and 2) develop, integrate, optimize, validate, translate or accelerate adoption of promising tools, methods and techniques: a) that fulfill an unmet need and address specific research or clinical problem in basic, translational, and/or clinical science and practice, b) capable of enhancing our understanding of health and disease, and/or c) improve practice of medicine. Applications may propose design-directed, developmental, discovery-driven, or hypothesis-driven research, and this FOA is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical or translational science.

Research Objectives

Many major biomedical research problems are best addressed with a multidisciplinary approach that bridges life sciences and physical sciences. Principles and techniques in quantitative sciences such as physics, mathematics, chemistry, computer sciences, and engineering are increasingly applied to enable and advance biomedical research. Bioengineering approaches integrate principles from diverse technical and biomedical fields, and the resulting multi-disciplinary research provides new understanding, innovative technologies, and new products that improve basic knowledge, human health, and quality of life. This FOA seeks to encourage collaborations among investigators in the fields of quantitative science and physical science with biomedical researchers to catalyze the development of innovative bioengineering approaches to solve important problems in biomedical research, translational research, clinical investigations, and medical practice.

Significant projects may include, but are not limited to: development, validation, and translation of promising modalities for the disease continuum, including tools for risk prediction, screening, prevention, detection, diagnosis, disease progression, intervention, monitoring treatment response, prognosis, or survival; development of quantitative, predictive models of complex biological systems; integration and optimization of technologies that significantly increase sensitivity, specificity, positive predictive value, negative predictive value, efficiency, or throughput of analysis to address unsolved biological or medical questions; in vitro and in vivo models, cell/tissue culture systems and organoids that closely mimic physiological conditions and allow mechanistic studies or engineering and testing of delivery systems, molecules/cells/tissues for therapeutic purposes, therapeutics, implants, and prosthetics that may improve treatment and healthcare.

Innovation in this biomedical engineering FOA has a broad definition that includes development of new methods, ideas, or tools, integration of existing components into new combinations that deliver new and/or greater capabilities, new efficiencies, and/or greater effects. Overall impact of these advances may include improving our understanding of molecular mechanisms, reducing disparities in access to care, promoting wellness and independent living, increasing access to and utility of technologies to improve quality of life, reducing the cost and complexity of procedures, and/or increasing throughput, sensitivity, and specificity of diagnostic tests.

Applications Not Responsive to this FOA

The following types of studies are not responsive to this FOA. Applications proposing such studies will be considered non-responsive and will not be reviewed:

Applications that do not seek to demonstrate feasibility and/or potential utility of new capabilities or improvements for solution of problems in basic biomedical, pre-clinical, or clinical research, clinical care delivery, or accessibility will be considered nonresponsive to this funding opportunity announcement, for example:

• Pursuit of a biological or clinical hypothesis where no technology development is proposed;
• Using existing technologies that do not need modifications or adaptations to answer a biomedical question; and

Traditional biological hypothesis-driven research using unmodified existing technologies.

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Budget: The number of awards is dependent upon NIH budgets and the submission of a sufficient number of deserving applications. Application budgets are not limited but need to reflect the actual needs of the proposed project. The scope of the proposed project should determine the project period.

Deadline: February 05, 2025

Eligibility: Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

The purpose of this funding opportunity announcement (FOA) is to encourage collaborations between the life and physical sciences that: 1) apply a multidisciplinary bioengineering approach to the solution of a biomedical problem; and 2) integrate, optimize, validate, translate or otherwise accelerate the adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, or clinical science and practice. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research and is appropriate for small teams applying an integrative approach to increase our understanding of and solve problems in biological, clinical, or translational science.

This FOA will support clinical trials that test functionality or validate performance in the chosen setting. This FOA is not intended to support conventional clinical trials that lack translation as the primary motivation. Applications that propose phase III clinical trials in any area of research are not sought by and will not be supported through this FOA. This FOA does not propose to support commercial production

Research Objectives

Many major biomedical research problems are best addressed with a multidisciplinary approach that bridges the life and physical sciences. Principles and techniques in quantitative sciences such as physics, mathematics, chemistry, computer sciences, and engineering are increasingly applied to good effect in biomedical research. Bioengineering approaches integrate principles from diverse technical and biomedical fields, and the resulting multi-disciplinary research provides new understanding, innovative technologies, and new products that improve basic knowledge, human health, and quality of life. This FOA seeks to encourage collaborations of quantitative and physical scientists with biomedical researchers to catalyze the development of innovative bioengineering approaches to the solution of important problems in biomedical research, clinical investigations, and medical practice.

Significant projects may include, but are not limited to: validation and translation of promising tools for prevention, monitoring or intervention; development of quantitative, predictive models of complex biological systems; integration and optimization of technologies that significantly increase sensitivity, specificity, positive predictive value, negative predictive value, efficiency, or throughput of measurements to address unsolved biological or medical questions; or engineering and testing of delivery systems, tissues, therapeutics, implants, and prosthetics that may improve treatment and healthcare.

Innovation in this biomedical engineering FOA has a broad definition that includes development of new methods, ideas, or tools, integration of existing components into new combinations that deliver greater capabilities, new efficiencies, and/or greater effects. Overall impact of these advances may include reducing disparities in care, promoting wellness and independent living, increasing access to and utility of technologies to improve quality of life, reducing cost and complexity of procedures, and increasing throughput, sensitivity, and specificity of diagnostic tests.

This FOA will support clinical trials that test functionality or validate performance in the chosen setting. This FOA is not intended to support conventional clinical trials that lack translation as the primary motivation. Applications that propose phase III clinical trials in any area of research are not sought by and will not be supported through this FOA. This FOA does not propose to support commercial production.

Applications Not Responsive to this FOA

The following types of studies are not responsive to this FOA. Applications proposing such studies will be considered non-responsive and will not be reviewed:

• Late phase or randomized clinical trials (although studies using specimens from these trials are appropriate);
• Applications that propose phase III clinical trials in any area of research are not responsive to this FOA.

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The CURE Epilepsy Catalyst Award (2 years / $250,000) supports nimble development of data necessary to advance ideas toward larger commercialization funding opportunities and is not intended to replace those opportunities.

Requests may be made for up to a total of $250,000 paid over 2 years. Funding requests may include salary support for the PI, technical staff and/or collaborators, supplies, animal costs, etc., and travel to an epilepsy-related conference if the PI is presenting his/her CURE Epilepsy-funded research. Limited equipment purchases that are required to complete goals will be considered. Indirect costs are not supported.

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The Rare Epilepsy Partnership Award (1 year / $100,000) will support the development of necessary research tools, techniques, model systems, and data collection platforms to stimulate and accelerate research on rare epilepsies. Each award will be co-funded by CURE Epilepsy and one or more of the rare epilepsy advocacy groups (partners) identified in the Request For Proposals. Applications must focus on one or more of the specific rare epilepsies that are represented by each group as well as address CURE Epilepsy’s mission to cure epilepsy.

Budget : Funding requests must be itemized and based on specific, milestone-defined scientific aims. Requestsmay be made for up to a maximum of $100,000 paid over one year. CURE Epilepsy reserves the right to fund only select specific aims or stage funding of proposals based on the achievement of milestones. Budgets may include salary support for the Principal Investigator (PI), technical staff and/or co-PIs, supplies, animal costs, vendor costs, limited equipment costs, and travel to an epilepsy-related conference only if the PI is presenting his/her CURE Epilepsy-funded research. Indirect costs are not supported.

This award is available to both established and early-career investigators. Established investigators are university faculty at the associate professor level or above, or investigators who hold an equivalent position in a non-university research organization. Early career investigators are defined as a) university faculty at the assistant professor level or hold an equivalent position in a non-university research organization, b) researchers with an appointment as an instructor or research assistant professor, c) post-doctoral fellows with at least three years of post-doctoral experience or d) clinical fellows. Early career investigators must have a mentor committed to advising the applicant.

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Deadline: 21 May 2025

Grant funding: Pathfinder Open – grants of up to EUR 3 million or more if duly justified Pathfinder projects can also receive additional funding for testing the innovation potential of their research outputs.

Do you have an ambitious vision for a novel future technology that could make a real difference to our lives?

• Do you see a plausible way of achieving the scientific breakthrough that will

make this technology possible?

• Can you imagine collaborating with an interdisciplinary team of researchers and innovators to validate the scientific basis of the future technology, realise a proof of principle, and explore paths to impact?

If the answer to each one of these questions is ‘yes’, then EIC Pathfinder Open may be the right call for you.

The EIC Pathfinder is a funding programme under Horizon Europe that offers support to research teams by:

• funding research to develop the scientific basis to underpin breakthrough technologies
• supporting the earliest stages of scientific, technological or deep-tech R&D
• aiming to build on new, cutting-edge directions in science and technology to disrupt a field and a market or create new opportunities
• realising innovative technological solutions to identify, develop and scale up breakthrough technologies and disruptive innovations in Europe

‘EIC Pathfinder Open’ open to support projects in any field of science, technology or application without predefined thematic priorities.

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Budget: between $25,000 and $75,000

The Alliance’s next Research Grant Cycle will open November 1, 2024

The goal of the PCDH19 Alliance Research Grant Program is to fund research directly towards understanding the expression of the PCDH19 gene and the function of the PCDH19 protein, finding therapeutic treatments, and a cure for PCDH19 Epilepsy.

We also hope that the projects we fund will lead to additional research support from government or other funding agencies. We are pleased to be able to support many different types of projects, each critical for advancing all phases of PCDH19 research, from basic to clinical to treatment.

These grants are crucial for allowing investigators to gain enough data to be able to attract even larger, multi-year commitments from the National Institutes of Health (NIH) and other traditional medical research funding organizations. The PCDH19 Alliance Research Grant Program awards one year grants between $25,000 and $75,000. The number of awards is contingent upon the availability of funds for that cycle.