Find here all the scientific publications written by EpiCARE members

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  • van den Munckhof, B., Arzimanoglou, A., Perucca, E., van Teeseling, H. C., Leijten, F., Braun, K., Jansen, F. E., & RESCUE ESES study group (2020). Corticosteroids versus clobazam in epileptic encephalopathy with ESES: a European multicentre randomised controlled clinical trial (RESCUE ESES*). Trials21(1), 957. https://doi.org/10.1186/s13063-020-04874-2
Epilepsy develops in 70 to 90% of children with tuberous sclerosis complex (TSC) and is often resistant to medication. Recently, the concept of preventive antiepileptic treatment to modify the natural history of epilepsy has been proposed. EPISTOP was a clinical trial designed to compare preventive versus conventional antiepileptic treatment in TSC infants”.
  • Kotulska, K., Kwiatkowski, D. J., Curatolo, P., Weschke, B., Riney, K., Jansen, F., Feucht, M., Krsek, P., Nabbout, R., Jansen, A. C., Wojdan, K., Sijko, K., Głowacka-Walas, J., Borkowska, J., Sadowski, K., Domańska-Pakieła, D., Moavero, R., Hertzberg, C., Hulshof, H., Scholl, T., … EPISTOP Investigators (2021). Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial. Annals of neurology89(2), 304–314. https://doi.org/10.1002/ana.25956

This European multicentre randomised controlled trial is designed to compare the effects of corticosteroids and clobazam on cognitive functioning after 6 months. Secondary outcomes include cognitive functioning after 18 months, EEG abnormalities in sleep, safety and tolerability, and seizure frequency. We also aimed at investigating whether treatment response in epileptic encephalopathy with ESES can be predicted by measurement of inflammatory mediators and autoantibodies in serum”.

  • Barba, C., Cossu, M., Guerrini, R., Di Gennaro, G., Villani, F., De Palma, L., Grisotto, L., Consales, A., Battaglia, D., Zamponi, N., d’Orio, P., Revay, M., Rizzi, M., Casciato, S., Esposito, V., Quarato, P. P., Di Giacomo, R., Didato, G., Pastori, C., Pavia, G. C., … Tassi, L. (2021). Temporal lobe epilepsy surgery in children and adults: A multicenter study. Epilepsia62(1), 128–142. https://doi.org/10.1111/epi.16772

“Clinical differences between adult and pediatric patients undergoing TLE surgery are reflected in differences in long-term outcomes and predictors of failures. Children are more likely to achieve sustained seizure freedom and withdraw AEDs after TLE surgery. Earlier referral should be encouraged as it can improve surgical outcome.

  • Pressler, R. M., Cilio, M. R., Mizrahi, E. M., Moshé, S. L., Nunes, M. L., Plouin, P., Vanhatalo, S., Yozawitz, E., de Vries, L. S., Puthenveettil Vinayan, K., Triki, C. C., Wilmshurst, J. M., Yamatomo, H., & Zuberi, S. M. (2021). The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures.  Epilepsia, 10.1111/epi.16815. Advance online publication. https://doi.org/10.1111/epi.16815

The International League Against Epilepsy (ILAE) presents a new classification and framework for seizures in the neonatal period in line with 2017 ILAE classifications.

  • Blumcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C. G., Pfäfflin, M., Elger, C., Widman, G., Schramm, J., Becker, A., Braun, K. P., Leijten, F., Baayen, J. C., Aronica, E., Chassoux, F., Hamer, H., Stefan, H., Rössler, K., Thom, M., … EEBB Consortium (2017). Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. The New England journal of medicine377(17), 1648–1656. https://doi.org/10.1056/NEJMoa1703784

“Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%).”

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  • Lamberink, H. J., Otte, W. M., Blümcke, I., Braun, K., European Epilepsy Brain Bank writing group, study group, & European Reference Network EpiCARE (2020). Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. The Lancet. Neurology19(9), 748–757. https://doi.org/10.1016/S1474-4422(20)30220-9

“Histopathological diagnosis, age at surgery, and duration of epilepsy are important prognostic factors for outcomes of epilepsy surgery. In every patient with refractory focal epilepsy presumed to be lesional, evaluation for surgery should be considered.”

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  • Baumgartner, TCarreño, MRocamora, R, et al. A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsiesEpilepsia Open20216160– 170https://doi.org/10.1002/epi4.12459

“The survey summarizes the current clinical practice for selected rare epilepsies in tertiary European epilepsy centers and demonstrates consistency as well as heterogeneity in the treatment, underscoring the need for controlled trials and recommendations. The survey also provides estimates for potential participants of clinical trials recruited via EpiCARE, emphasizing the great potential of Reference Networks for future studies to evaluate new targeted therapies and to identify novel biomarkers.”

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