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Scientific publications

Find here scientific publications written by EpiCARE members.

Epilepsy surgery related publications
Kobulashvili, T., Höfler, J., Dobesberger, J., Ernst, F., Ryvlin, P., Cross, J. H., Braun, K., Dimova, P., Francione, S., Hecimovic, H., Helmstaedter, C., Kimiskidis, V. K., Lossius, M. I., Malmgren, K., Marusic, P., Steinhoff, B. J., Boon, P., Craiu, D., Delanty, N., Fabo, D., … Trinka, E. (2016).

Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery. Seizure, 38, 38–45. Find the publication here.

“The European Union-funded E-PILEPSY network aims to improve awareness of, and accessibility to, epilepsy surgery across Europe. In this study we assessed current clinical practices in epilepsy monitoring units (EMUs) in the participating centers.”
Kobulashvili, T., Kuchukhidze, G., Brigo, F., Zimmermann, G., Höfler, J., Leitinger, M., Dobesberger, J., Kalss, G., Rohracher, A., Neuray, C., Wakonig, A., Ernst, F., Braun, K., Mouthaan, B. E., Van Eijsden, P., Ryvlin, P., Cross, J. H., Trinka, E., & E-PILEPSY consortium (2018).

Diagnostic and prognostic value of noninvasive long-term video-electroencephalographic monitoring in epilepsy surgery: A systematic review and meta-analysis from the E-PILEPSY consortium. Epilepsia, 59(12), 2272–2283. Find the publication here.

“The European Union-funded E-PILEPSY network (now continuing within the European Reference Network for rare and complex epilepsies [EpiCARE]) aims to harmonize and optimize presurgical diagnostic procedures by creating and implementing evidence-based guidelines across Europe. The present study evaluates the current evidence on the diagnostic accuracy of long-term video-electroencephalographic monitoring (LTM) in identifying the epileptogenic zone in epilepsy surgery candidates.”
Mouthaan, B. E., Rados, M., Boon, P., Carrette, E., Diehl, B., Jung, J., Kimiskidis, V., Kobulashvili, T., Kuchukhidze, G., Larsson, P. G., Leitinger, M., Ryvlin, P., Rugg-Gunn, F., Seeck, M., Vulliémoz, S., Huiskamp, G., Leijten, F., Van Eijsden, P., Trinka, E., Braun, K., … E-PILEPSY consortium (2019).

Diagnostic accuracy of interictal source imaging in presurgical epilepsy evaluation: A systematic review from the E-PILEPSY consortium. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 130(5), 845–855. Find the publication here.

“Interictal high resolution (HR-) electric source imaging (ESI) and magnetic source imaging (MSI) are non-invasive tools to aid epileptogenic zone localization in epilepsy surgery candidates. We carried out a systematic review on the diagnostic accuracy and quality of evidence of these modalities.”
Mouthaan, B. E., Rados, M., Barsi, P., Boon, P., Carmichael, D. W., Carrette, E., Craiu, D., Cross, J. H., Diehl, B., Dimova, P., Fabo, D., Francione, S., Gaskin, V., Gil-Nagel, A., Grigoreva, E., Guekht, A., Hirsch, E., Hecimovic, H., Helmstaedter, C., Jung, J., … E-PILEPSY consortium (2016).

Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe. Epilepsia, 57(5), 770–776. Find the publication here.

“In 2014 the European Union-funded E-PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic source localization, and imaging postprocessing procedures in participating centers.”
Schmid, E., Thomschewski, A., Taylor, A., Zimmermann, G., Kirschner, M., Kobulashvili, T., Brigo, F., Rados, M., Helmstaedter, C., Braun, K., Trinka, E., & E-PILEPSY consortium (2018).

Diagnostic accuracy of functional magnetic resonance imaging, Wada test, magnetoencephalography, and functional transcranial Doppler sonography for memory and language outcome after epilepsy surgery: A systematic review. Epilepsia, 59 (12), 2305–2317. Find the publication here.

“In this systematic review, we aimed to assess the diagnostic accuracy of functional magnetic resonance imaging (fMRI), Wada test, magnetoencephalography (MEG), and functional transcranial Doppler sonography (fTCD) for memory and language decline after surgery.”
Vogt, V. L., Äikiä, M., Del Barrio, A., Boon, P., Borbély, C., Bran, E., Braun, K., Carette, E., Clark, M., Cross, J. H., Dimova, P., Fabo, D., Foroglou, N., Francione, S., Gersamia, A., Gil-Nagel, A., Guekht, A., Harrison, S., Hecimovic, H., Heminghyt, E., … E-PILEPSY consortium (2017).

Current standards of neuropsychological assessment in epilepsy surgery centers across Europe. Epilepsia, 58 (3), 343–355. Find the publication here.

The International League Against Epilepsy (ILAE) presents a new classification and framework for seizures in the neonatal period in line with 2017 ILAE classifications.
Other publications
Ryvlin, P., & Nguyen, D. K. (2021).

Insular seizures and epilepsies: Ictal semiology and minimal invasive surgery. Current opinion in neurology, 34(2), 153–165. Find the publication here.

“Significant progress has been made in the identification and surgical treatment of insular and insulo-opercular epilepsies, including more precise anatomo-clinical correlations to optimally plan SEEG investigations, and experience in using minimal invasive surgery to reduce peri-operative morbidity.”
Mikati, M. A., Panagiotakaki, E., & Arzimanoglou, A. (2021).

Revision of the diagnostic criteria of alternating hemiplegia of childhood. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, S1090-3798(21)00099-4. Advance online publication. Find the publication here.
Van den Munckhof, B., Arzimanoglou, A., Perucca, E., van Teeseling, H. C., Leijten, F., Braun, K., Jansen, F. E., & RESCUE ESES study group (2020).

Corticosteroids versus clobazam in epileptic encephalopathy with ESES: a European multicentre randomised controlled clinical trial (RESCUE ESES*). Trials, 21(1), 957. Find the publication here.

“Epilepsy develops in 70 to 90% of children with tuberous sclerosis complex (TSC) and is often resistant to medication. Recently, the concept of preventive antiepileptic treatment to modify the natural history of epilepsy has been proposed. EPISTOP was a clinical trial designed to compare preventive versus conventional antiepileptic treatment in TSC infants”.
Kotulska, K., Kwiatkowski, D. J., Curatolo, P., Weschke, B., Riney, K., Jansen, F., Feucht, M., Krsek, P., Nabbout, R., Jansen, A. C., Wojdan, K., Sijko, K., Głowacka-Walas, J., Borkowska, J., Sadowski, K., Domańska-Pakieła, D., Moavero, R., Hertzberg, C., Hulshof, H., Scholl, T., … EPISTOP Investigators (2021).

Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial. Annals of neurology, 89(2), 304–314. Find the publication here.

“This European multicentre randomised controlled trial is designed to compare the effects of corticosteroids and clobazam on cognitive functioning after 6 months. Secondary outcomes include cognitive functioning after 18 months, EEG abnormalities in sleep, safety and tolerability, and seizure frequency. We also aimed at investigating whether treatment response in epileptic encephalopathy with ESES can be predicted by measurement of inflammatory mediators and autoantibodies in serum”.
Barba, C., Cossu, M., Guerrini, R., Di Gennaro, G., Villani, F., De Palma, L., Grisotto, L., Consales, A., Battaglia, D., Zamponi, N., d’Orio, P., Revay, M., Rizzi, M., Casciato, S., Esposito, V., Quarato, P. P., Di Giacomo, R., Didato, G., Pastori, C., Pavia, G. C., … Tassi, L. (2021).

Temporal lobe epilepsy surgery in children and adults: A multicenter study. Epilepsia, 62(1), 128–142. Find the publication here.

“Clinical differences between adult and pediatric patients undergoing TLE surgery are reflected in differences in long-term outcomes and predictors of failures. Children are more likely to achieve sustained seizure freedom and withdraw AEDs after TLE surgery. Earlier referral should be encouraged as it can improve surgical outcome.“
Pressler, R. M., Cilio, M. R., Mizrahi, E. M., Moshé, S. L., Nunes, M. L., Plouin, P., Vanhatalo, S., Yozawitz, E., de Vries, L. S., Puthenveettil Vinayan, K., Triki, C. C., Wilmshurst, J. M., Yamatomo, H., & Zuberi, S. M. (2021).

The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate. Position paper by the ILAE Task Force on Neonatal Seizures. Epilepsia, 10.1111/epi.16815. Advance online publication. Find the publication here.

The International League Against Epilepsy (ILAE) presents a new classification and framework for seizures in the neonatal period in line with 2017 ILAE classifications.
Blumcke, I., Spreafico, R., Haaker, G., Coras, R., Kobow, K., Bien, C. G., Pfäfflin, M., Elger, C., Widman, G., Schramm, J., Becker, A., Braun, K. P., Leijten, F., Baayen, J. C., Aronica, E., Chassoux, F., Hamer, H., Stefan, H., Rössler, K., Thom, M., … EEBB Consortium (2017).

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery. The New England journal of medicine, 377(17), 1648–1656. Find the publication here.

“Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%).”

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Lamberink, H. J., Otte, W. M., Blümcke, I., Braun, K., European Epilepsy Brain Bank writing group, study group, & European Reference Network EpiCARE (2020).

Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study. The Lancet. Neurology, 19(9), 748–757. Find the publication here.

“Histopathological diagnosis, age at surgery, and duration of epilepsy are important prognostic factors for outcomes of epilepsy surgery. In every patient with refractory focal epilepsy presumed to be lesional, evaluation for surgery should be considered.”

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Baumgartner, T, Carreño, M, Rocamora, R, et al.

A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies. Epilepsia Open. 2021; 6: 160– 170. Find the publication here.

“The survey summarizes the current clinical practice for selected rare epilepsies in tertiary European epilepsy centers and demonstrates consistency as well as heterogeneity in the treatment, underscoring the need for controlled trials and recommendations. The survey also provides estimates for potential participants of clinical trials recruited via EpiCARE, emphasizing the great potential of Reference Networks for future studies to evaluate new targeted therapies and to identify novel biomarkers.”

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Vetro, A., Nielsen, H. N., Holm, R., Hevner, R. F., Parrini, E., Powis, Z., Møller, R. S., Bellan, C., Simonati, A., Lesca, G., Helbig, K. L., Palmer, E. E., Mei, D., Ballardini, E., Haeringen, A. V., Syrbe, S., Leuzzi, V., Cioni, G., Curry, C. J., Costain, G., … Guerrini, R. (2021).

ATP1A2- and ATP1A3-associated early profound epileptic encephalopathy and polymicrogyria. Brain : a journal of neurology, awab052. Advance online publication. Find the publication here.
Beniczky, S., Aurlien, H., Franceschetti, S., Martins da Silva, A., Bisulli, F., Bentes, C., Canafoglia, L., Ferri, L., Krýsl, D., Rita Peralta, A., Rácz, A., Cross, J. H., & Arzimanoglou, A. (2020). Interrater agreement of classification of photoparoxysmal electroencephalographic response. Epilepsia, 61(9), e124–e128. Find the publication here.